Sound stimulation increases calcium-binding protein immunoreactivity in the inferior colliculus in mice.
Neurosci Lett
; 259(1): 49-52, 1999 Jan 04.
Article
em En
| MEDLINE
| ID: mdl-10027553
ABSTRACT
The numerical density of calbindin D-28k and parvalbumin immunopositive neurons in the inferior colliculus (IC) in mice was increased after sound stimulation. An increased number of calbindin positive neurons was found in the deep layers of the external cortex (EC) and particularly in the dorsal cortex (DC) and commissural nucleus (NCO). An increase of parvalbumin positive neurons was found in the EC, central nucleus (ICC) and DC, but not in the NCO. The increased immunoreactivity related to sound exposure suggests the appearance of neurons which express these proteins after sound stimulation. The up-regulation of calcium-binding proteins in these neurons may be due to their protective role against overstimulation, their response to a higher auditory metabolic activity, or increasing effect of excitatory inputs after noise-induced hearing loss.
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Base de dados:
MEDLINE
Assunto principal:
Estimulação Acústica
/
Proteínas de Ligação ao Cálcio
/
Colículos Inferiores
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article