Aspergillus meningitis: diagnosis by non-culture-based microbiological methods and management.
J Clin Microbiol
; 37(4): 1186-9, 1999 Apr.
Article
em En
| MEDLINE
| ID: mdl-10074549
ABSTRACT
The performance of antibody detection, antigen detection, and Aspergillus genus-specific PCR for diagnosing Aspergillus meningitis was investigated with 26 cerebrospinal fluid (CSF) samples obtained from a single patient with proven infection caused by Aspergillus fumigatus. Immunoglobulin G antibodies directed against Aspergillus were not detected by enzyme-linked immunosorbent assay in CSF or serum. The antigen galactomannan was detected in the CSF 45 days before a culture became positive, and Aspergillus DNA was detected 4 days prior to culture. Decline of the galactomannan antigen titer in the CSF during treatment with intravenous and intraventricular amphotericin B and intravenous voriconazole corresponded with the clinical response to treatment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aspergilose
/
Meningite Fúngica
/
Micologia
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article