Spinal administration of selective opioid antagonists in amphibians: evidence for an opioid unireceptor.
Life Sci
; 64(10): PL125-30, 1999.
Article
em En
| MEDLINE
| ID: mdl-10096442
ABSTRACT
In mammals, opioids act by interactions with three distinct types of receptors mu, delta, or kappa opioid receptors. Using a novel assay of antinociception in the Northern grass frog, Rana pipiens, previous work demonstrated that selective mu, delta, or kappa opioids produced a potent antinociception when administered by the spinal route. The relative potency of this effect was highly correlated to that found in mammals. Present studies employing selective opioid antagonists, beta-FNA, NTI, or nor-BNI demonstrated that, in general, these antagonists were not selective in the amphibian model. These data have implications for the functional evolution of opioid receptors in vertebrates and suggest that the tested mu, delta, and kappa opioids mediate antinociception via a single type of opioid receptor in amphibians, termed the unireceptor.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Rana pipiens
/
Receptores Opioides
/
Antagonistas de Entorpecentes
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article