New lines of host defense: inhibition of Ty1 retrotransposition by Fus3p and NER/TFIIH.
Trends Genet
; 15(2): 43-5, 1999 Feb.
Article
em En
| MEDLINE
| ID: mdl-10098404
ABSTRACT
The genomes of all organisms examined contain transposons whose uncontrolled movement threatens genome function. Fortunately, host cells have evolved defense mechanisms to minimize the level of transposition. In this review we discuss recent work showing that proteins involved in signal transduction and RNA transcription/DNA repair inhibit Ty1 retrotransposition in the yeast Saccharomyces cerevisiae. On the basis of these examples, we hypothesize that the level of Ty1 retrotransposition may be modulated in response to environmental stress signals that affect cellular differentiation and DNA repair.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Proteínas Fúngicas
/
Elementos de DNA Transponíveis
/
Mutagênese Insercional
/
Proteínas Quinases Ativadas por Mitógeno
/
Proteínas de Saccharomyces cerevisiae
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article