Sympathetic-parasympathetic interactions at the heart in the anaesthetised rat.
J Auton Nerv Syst
; 75(2-3): 171-5, 1999 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-10189119
ABSTRACT
This study observed the effects of stimulation of the cardiac sympathetic nerve on vagal slowing of the heart in rats, and compared these with any actions of exogenous neuropeptide Y (NPY) and galanin (GAL). In rats anaesthetised with pentobarbitone, stimulation of the cardiac sympathetic nerve for 2 min at 20 Hz in the rat evoked an attenuation of subsequent cardiac vagal action, which could be mimicked by exogenous NPY, but not GAL. The galanin antagonist, GAL1-13/NPY24-36, known to block the inhibitory action of galanin on the cardiac vagus in cats, did not alter the effect of sympathetic stimulation on cardiac vagal activity. We suggest on the basis of results here that in the rat, NPY released during stimulation of the cardiac sympathetic nerve, causes inhibition of acetylcholine release from the vagus nerve.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Parassimpático
/
Sistema Nervoso Simpático
/
Coração
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article