Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression.
Nat Neurosci
; 1(7): 579-86, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-10196565
ABSTRACT
The mechanisms responsible for enhanced transmission during long-term potentiation (LTP) at CA1 hippocampal synapses remain elusive. Several popular models for LTP expression propose an increase in 'use' of existing synaptic elements, such as increased probability of transmitter release or increased opening of postsynaptic receptors. To test these models directly, we studied a GluR2 knockout mouse in which AMPA receptor transmission is rendered sensitive to a use-dependent block by polyamine compounds. This method can detect increases during manipulations affecting transmitter release or AMPA receptor channel open time and probability, but shows no such changes during LTP. Our results indicate that the recruitment of new AMPA receptors and/or an increase in the conductance of these receptors is responsible for the expression of CA1 LTP.
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Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Receptores de AMPA
/
Camundongos Knockout
/
Potenciação de Longa Duração
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article