Differential regulation of killer cell Ig-like receptors and CD94 lectin-like dimers on NK and T lymphocytes from HIV-1-infected individuals.
Eur J Immunol
; 29(4): 1076-85, 1999 04.
Article
em En
| MEDLINE
| ID: mdl-10229073
ABSTRACT
NK and T lymphocytes share various cell surface receptors, including NK receptors for MHC class I molecules (NKR). NKR include killer cell Ig-like receptors (KIR) and lectin-like dimers which are composed of the invariant CD94 associated with a variety of NKG2 molecules. The combination of KIR and CD94/NKG2 dimers expressed on NK and T cell subsets defines a repertoire of MHC class I recognition. Engagement of NKR by cognate MHC class I molecules governs T and NK cell activation. We investigated the NKR distribution on NK and T cell subsets from uninfected and HIV-infected individuals, according to the clinical status, the absolute numbers of CD4+ T cells as well as the plasmatic viral load of the patients. We show that the KIR distribution on NK cells is not affected by HIV-1 infection, whereas the absolute numbers of T cells expressing specific KIR members (CD158b, p70) transiently increase in early stages of HIV infection. By contrast, the percentages of NK and T cells which express CD94 dimers increase in parallel with the disease. These results document a differential regulation of KIR and CD94 lectin-like dimers during the course of a chronic viral infection in humans and further suggest that both types of NKR are independently regulated.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Células Matadoras Naturais
/
Receptores Imunológicos
/
Linfócitos T
/
Antígenos CD
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Síndrome da Imunodeficiência Adquirida
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HIV-1
/
Lectinas Tipo C
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article