[The effects of staphylococcal alpha toxin on regenerating liver (author's transl)]. / Effetti della tossina stafilococcica alfa sulla rigenerazione epatica

ABSTRACT

The effects of staphylococcal alpha toxin on regenerating liver of partially hepatectomized rats are studied. Sixty six rats are used. They are divided into three groups of twenty two animals each one. The first group included untreated animals, the rats of second and third group are injected with 0,1 UE of staphylococcal alpha toxin, respectively soon after hepatectomy (second group) and after twenty two hours (third group). As parameters we used mitotic activity, percentage of hepatic regeneration, the contents of liver water and proteins. The results are a low letality in all the animals, a lower mitotic activity in all treated animals than in the intact ones, the percentage of restoration, the contents of water and proteins are the same in all the animals of the three groups. The AA. conclude that staphylococcal alpha toxin has a little negative mitotic effect on partially hepatectomized rats liver.