A qualitative estimate of the influence of halcinonide concentration and urea on the reservoir formation in the stratum corneum.
Skin Pharmacol Appl Skin Physiol
; 12(1-2): 85-9, 1999.
Article
em En
| MEDLINE
| ID: mdl-10325587
ABSTRACT
The existence of a stratum corneum reservoir for topically applied substances is well known. Data concerning the stratum corneum retention time are important for the elaboration of optimal topical treatment. We used the re-occlusion technique followed by skin colour measurements (Chromametry) for the evaluation of the stratum corneum retention time of halcinonide. We found a significant reservoir for halcinonide up to 5 days after the initial application. The retention was found to be corticosteroid concentration and formulation dependent.
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Base de dados:
MEDLINE
Assunto principal:
Ureia
/
Halcinonida
/
Epiderme
/
Anti-Inflamatórios
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article