Bile acids: natural ligands for an orphan nuclear receptor.
Science
; 284(5418): 1365-8, 1999 May 21.
Article
em En
| MEDLINE
| ID: mdl-10334993
ABSTRACT
Bile acids regulate the transcription of genes that control cholesterol homeostasis through molecular mechanisms that are poorly understood. Physiological concentrations of free and conjugated chenodeoxycholic acid, lithocholic acid, and deoxycholic acid activated the farnesoid X receptor (FXR; NR1H4), an orphan nuclear receptor. As ligands, these bile acids and their conjugates modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1. These results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Ácidos e Sais Biliares
/
Ácido Quenodesoxicólico
/
Receptores Citoplasmáticos e Nucleares
/
Transportadores de Ânions Orgânicos Dependentes de Sódio
/
Simportadores
/
Proteínas de Ligação a DNA
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article