Preliminary evidence of low cortical GABA levels in localized 1H-MR spectra of alcohol-dependent and hepatic encephalopathy patients.
Am J Psychiatry
; 156(6): 952-4, 1999 Jun.
Article
em En
| MEDLINE
| ID: mdl-10360140
ABSTRACT
OBJECTIVE:
The aim of the study was to compare levels of neuroactive amino acids in the cerebral cortex of healthy subjects, recently detoxified alcohol-dependent patients, and patients with hepatic encephalopathy.METHOD:
Metabolite levels were measured in the occipital cortex by using spatially localized 1H-MRS. Five recently detoxified alcohol-dependent and five hepatic encephalopathy patients with alcohol and non-alcohol-related disease were compared with 10 healthy subjects.RESULTS:
The combined level of gamma-aminobutyric acid (GABA) plus homocarnosine was lower in the alcohol-dependent and hepatic encephalopathy patients than in the healthy subjects.CONCLUSIONS:
The findings suggest that GABA-ergic systems are altered in both alcohol-dependent and hepatic encephalopathy patients.
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Base de dados:
MEDLINE
Assunto principal:
Espectroscopia de Ressonância Magnética
/
Córtex Cerebral
/
Encefalopatia Hepática
/
Alcoolismo
/
Ácido gama-Aminobutírico
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article