Effect of catecholamine depletion on lithium-induced long-term remission of bipolar disorder.
Biol Psychiatry
; 45(8): 972-8, 1999 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-10386179
ABSTRACT
BACKGROUND:
This study investigated the effects of catecholamine depletion with alpha-methylparatyrosine (AMPT) on mood indices in patients with bipolar disorder who were in long-term remission with lithium therapy.METHODS:
Eight subjects with DSM-IV bipolar disorder currently in remission for > 3 months on lithium were included in the study. Subjects were given either AMPT or placebo, in a randomized double-blind manner, in two test sessions of 4 days each.RESULTS:
Subjects did not have any significant changes in mood during AMPT or placebo administration; however, 24-48 hours after the last active AMPT dose subjects had a transient relapse of hypomanic symptoms. Relapse of hypomanic symptoms did not correlate with increases in serum levels of homovanillic acid or 3-methoxy-4-hydroxyphenylglycol.CONCLUSIONS:
These findings suggest that the mechanism of prevention of manic relapse by long-term lithium therapy may be dependent on stability of the catecholamine system.
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Base de dados:
MEDLINE
Assunto principal:
Transtorno Bipolar
/
Catecolaminas
/
Antimaníacos
/
Alfa-Metiltirosina
/
Inibidores Enzimáticos
/
Lítio
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article