Cytokine induction and modifying the immune response to human papilloma virus with imiquimod.
Eur J Dermatol
; 8(7 Suppl): 13-6; discussion 20-2, 1998.
Article
em En
| MEDLINE
| ID: mdl-10387958
ABSTRACT
Imiquimod is the newest in a class of drugs known as immune response modifiers. In preclinical studies, imiquimod induced the production of cytokines - the principal cytokine for antiviral activity being interferon alpha. Imiquimod does not inhibit viruses directly, nor does it cause direct, non-specific cytolytic destruction [1]. Preclinical studies suggest that its antiviral action results from in vivo cytokine-induced activation of the immune system. This paper reviews a recent double blind, placebo-controlled study designed to evaluate this hypothesis. The results of this study showed that wart regression following treatment with imiquimod strongly correlated with a decrease in viral DNA and gene transcripts; a decrease in mRNA expression for proteins associated with cellular proliferation, and an increase in keratinocyte markers. These results support the hypothesis that stimulation of local cytokines by imiquimod leads to a reduction in human papilloma virus (HPV) load; to wart regression and to the normalisation of keratinocyte proliferation without evidence of scarring.
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Base de dados:
MEDLINE
Assunto principal:
Papillomaviridae
/
Infecções Tumorais por Vírus
/
Adjuvantes Imunológicos
/
Citocinas
/
Indutores de Interferon
/
Infecções por Papillomavirus
/
Aminoquinolinas
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article