Antibodies engineered with IgD specificity efficiently deliver integrated T-cell epitopes for antigen presentation by B cells.
Nat Biotechnol
; 17(7): 670-5, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10404160
ABSTRACT
We have developed a strategy for improving the stimulation of T cells during immune responses by constructing recombinant antibodies that enhance the delivery of antigen to antigen-presenting cells, such as B cells. These antibodies have variable regions specific for surface molecules on B cells, and a constant region with an inserted antigen. In vitro, such antibodies make B cells approximately 1000-fold more efficient at presenting antigen and stimulating specific T cells. In vivo, the antibodies turn B cells of the spleen into potent stimulators of T cells. This approach may be useful for the generation of new vaccines.
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Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina D
/
Linfócitos B
/
Linfócitos T
/
Engenharia de Proteínas
/
Anticorpos
/
Epitopos
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article