Pyrimidine nucleotidases/phosphotransferases from human erythrocyte.
Nucleosides Nucleotides
; 18(4-5): 853-5, 1999.
Article
em En
| MEDLINE
| ID: mdl-10432693
ABSTRACT
Two cytoplasmic pyrimidine 5'-nucleotidase have been purified from human erythrocytes to homogeneity and partially characterized. The two enzymes, indicated as PN-I and PN-II, preferentially hydrolyse pyrimidine 5'-monophosphates and 3'-monophosphates, respectively. The kinetic analysis demonstrate that pyrimidine 5'-nucleotidases, in the presence of suitable nucleoside substrates, can operate as phosphotransferases by transferring phosphate to various nucleoside acceptors, including nucleoside analogues known as important drugs widely used in chemotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Fosfotransferases
/
5'-Nucleotidase
/
Eritrócitos
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article