Intravitreal dexamethasone effect on intravitreal vancomycin elimination in endophthalmitis.
Arch Ophthalmol
; 117(8): 1058-62, 1999 Aug.
Article
em En
| MEDLINE
| ID: mdl-10448749
ABSTRACT
OBJECTIVE:
To determine whether intravitreal dexamethasone administration can alter the elimination of intravitreal vancomycin hydrochloride in rabbit eyes with experimental Streptococcus pneumoniae endophthalmitis.METHODS:
Albino rabbits were infected with an intravitreal inoculum of S pneumoniae (2 x 10(3) colony-forming units) and randomized after 24 hours to treatment with intravitreal vancomycin hydrochloride (1 mg), alone or in combination with intravitreal dexamethasone (400 microg). For comparison, uninfected eyes were similarly treated. All eyes were enucleated 24, 48, or 72 hours after treatment, and vitreous levels of vancomycin were quantitated using a fluorescence polarizing immunoassay.RESULTS:
The half-life of intravitreal vancomycin in infected eyes was prolonged from 48 to 84 hours when eyes were treated with dexamethasone. Conversely, such treatment shortened the half-life in uninfected eyes from 56 to 42 hours.CONCLUSIONS:
Intravitreal dexamethasone administration reduces the elimination of intravitreal vancomycin in rabbit eyes with pneumococcal endophthalmitis, whereas an opposite effect is noted in uninfected eyes. CLINICAL RELEVANCE In patients with eyes having endophthalmitis caused by virulent organisms, the elimination of intravitreal vancomycin may be reduced when intraocular inflammation is minimized with corticosteroid therapy. This may enhance the efficacy of intravitreal vancomycin therapy in treating the infection.
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Base de dados:
MEDLINE
Assunto principal:
Infecções Pneumocócicas
/
Corpo Vítreo
/
Dexametasona
/
Vancomicina
/
Infecções Oculares Bacterianas
/
Endoftalmite
/
Glucocorticoides
/
Antibacterianos
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article