Calcium channel activation stabilizes a neuronal calcium channel mRNA.
Nat Neurosci
; 2(9): 785-90, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10461216
ABSTRACT
We have identified a calcium-dependent pathway in neurons that regulates expression levels of the alpha1B subunit and N channel current. When neurons are depolarized and voltage-gated calcium channels activated, the half-life of cellular N channel alpha1B mRNA is prolonged. This stabilizing effect of depolarization is mediated through the 3' untranslated region of a long form of the alpha1B mRNA and may represent a form of modulation of N-channel levels that does not require changes in gene transcription. Increases in N channel expression would affect several key neuronal functions controlled by calcium, including transmitter release and neurite outgrowth.
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Base de dados:
MEDLINE
Assunto principal:
RNA Mensageiro
/
Canais de Cálcio
/
Regulação da Expressão Gênica
/
Gânglio Cervical Superior
/
Neurônios
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article