Impaired antibody response after immunization of HIV-infected individuals with the polysaccharide vaccine against Salmonella typhi (Typhim-Vi).
Vaccine
; 17(23-24): 2941-5, 1999 Aug 06.
Article
em En
| MEDLINE
| ID: mdl-10462227
ABSTRACT
Infections with Salmonella species, including Salmonella typhi, are more frequently observed in HIV-infected individuals than in healthy individuals. HIV-infected individuals were vaccinated with polysaccharide vaccine against Salmonella typhi (Typhim-Vi) which is assumed to be a T-cell-independent antigen. We found that the antibody response in patients with < 200 x 10(6)/l CD4+ T lymphocytes was significantly lower compared with patients with > or = 200 x 10(6)/l CD4+ T lymphocytes and healthy controls. The antibody response after vaccination with the polysaccharide salmonella Vi-antigen was correlated with the number of CD4+ T lymphocytes and therefore Typhim-Vi can be considered to be a T-cell-independent type 2 antigen. The results of this study indicate that after vaccination the proportion of HIV-infected individuals with protective antibody concentrations against Salmonella typhi will be lower than in healthy controls.
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Base de dados:
MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
/
Salmonella typhi
/
Febre Tifoide
/
Vacinas Tíficas-Paratíficas
/
Infecções por HIV
/
Anticorpos Antibacterianos
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article