A single targeted Ets2 allele restricts development of mammary tumors in transgenic mice.
Cancer Res
; 59(17): 4242-6, 1999 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-10485465
ABSTRACT
Heterozygous female mice carrying a targeted mutation of the Ets2 transcription factor gene were mated with a mouse strain that develops mammary tumors due to the expression of the polyoma virus middle T oncogene. Tumors from females with only one wild-type Ets2 gene were approximately one-half the size of tumors from controls. The smaller size of the tumors was correlated with a more differentiated state of early hyperplastic growths and not to differential growth of the frank tumors or to decreased middle T gene expression. Ets2 may regulate the progression of these aggressive mammary tumors.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Fatores de Transcrição
/
Transativadores
/
Proteínas Proto-Oncogênicas
/
Proteínas de Ligação a DNA
/
Alelos
/
Neoplasias Mamárias Experimentais
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article