MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans.
Mol Cell
; 4(2): 275-80, 1999 Aug.
Article
em En
| MEDLINE
| ID: mdl-10488343
ABSTRACT
In C. elegans, a Wnt/WG-like signaling pathway down-regulates the TCF/LEF-related protein, POP-1, to specify posterior cell fates. Effectors of this signaling pathway include a beta-catenin homolog, WRM-1, and a conserved protein kinase, LIT-1. WRM-1 and LIT-1 form a kinase complex that can directly phosphorylate POP-1, but how signaling activates WRM-1/LIT-1 kinase is not yet known. Here we show that mom-4, a genetically defined effector of polarity signaling, encodes a MAP kinase kinase kinase-related protein that stimulates the WRM-1/LIT-1-dependent phosphorylation of POP-1. LIT-1 kinase activity requires a conserved residue analogous to an activating phosphorylation site in other kinases, including MAP kinases. These findings suggest that anterior/posterior polarity signaling in C. elegans may involve a MAP kinase-like signaling mechanism.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Grupo de Alta Mobilidade
/
Proteínas Serina-Treonina Quinases
/
Caenorhabditis elegans
/
Proteínas do Citoesqueleto
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Proteínas de Caenorhabditis elegans
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Proteínas de Ligação a DNA
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Embrião não Mamífero
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Proteínas de Membrana
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article