The design of potent, selective, non-covalent, peptide thrombin inhibitors utilizing imidazole as a S1 binding element.
Bioorg Med Chem Lett
; 9(18): 2767-72, 1999 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-10509932
ABSTRACT
Modeling of neutral or mildly basic functional groups in the S1 site of thrombin led to the targeting of imidazole as a S1 binding element and correctly predicted the optimal chain length for connecting this group with the S2 and S3 binding elements. Derivatives of 4-(3-aminopropyl)-imidazole can be selective inhibitors of thrombin demonstrating potent anticoagulant activity.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Antitrombinas
/
Imidazóis
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article