Spliced leader-associated RNA from Crithidia fasciculata contains a structure resembling stem/loop II of U1 snRNA.
FEBS Lett
; 459(2): 215-7, 1999 Oct 08.
Article
em En
| MEDLINE
| ID: mdl-10518021
ABSTRACT
In contrast to earlier proposals, recent evidence suggests that trans-spliceosomes in trypanosomatid protozoa may contain a homolog of U1 small nuclear (sn) RNA (Schnare, M.N. and Gray, M.W. (1999) J. Biol. Chem. 274, 23,691-23,694). However, the candidate trypanosomatid U1 snRNA is unconventional because it lacks the highly conserved stem/loop II present in all other U1 snRNAs. Trypanosomatids also possess a unique spliced leader-associated (SLA) RNA of unknown function. We present the complete sequence of the SLA RNA from Crithidia fasciculata and propose that it may contribute a U1 snRNA-like stem/loop II to the trans-spliceosome.
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Base de dados:
MEDLINE
Assunto principal:
RNA de Protozoário
/
Crithidia fasciculata
/
RNA Líder para Processamento
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article