Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1.
J Control Release
; 62(1-2): 129-40, 1999 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-10518644
ABSTRACT
Non-invasive delivery of peptide and protein drugs will soon become a reality. This is due partly to a better understanding of the endogenous transport mechanisms, including paracellular transport, endocytosis, and carrier-mediated transport of mucosal routes of peptide and protein drug administration. This paper focuses on work related to the elucidation of structure-function, intracellular trafficking, and regulation of the intestinal dipeptide transporter, PepT1.
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Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Biofarmácia
/
Proteínas
/
Proteínas de Transporte
/
Simportadores
/
Dipeptídeos
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article