A new variant of GB virus C/hepatitis G virus (GBV-C/HGV) from South Africa.
Virus Res
; 64(2): 151-60, 1999 Nov.
Article
em En
| MEDLINE
| ID: mdl-10518711
ABSTRACT
Phylogenetic analysis of the 5' non-coding region (5'NCR) sequences has demonstrated that GB virus C/hepatitis G virus (GBV-C/HGV) can be separated into three major groups that correlate with the geographic origin of the isolate. Sequence analysis of the 5'NCR of 54 GBV-C/HGV isolates from 31 blood donors, 11 haemodialysis patients and 12 patients with chronic liver disease suggests the presence of a new variant of GBV-C/HGV in the province of KwaZulu Natal, South Africa. Eleven isolates grouped as group 1 variants (bootstrap support, 90%) found predominantly in West and Central Africa, a further six isolates grouped as group 2 variants (bootstrap support, 58%) found in Europe and North America; five of which grouped as 2a (bootstrap support, 91%) and one as 2b (bootstrap support, 87%), the latter also includes isolates from Japan, East Africa and Pakistan. Although the remaining 37 GBV-C/HGV isolates were more closely related to group 1 variants (bootstrap support, 90%), they formed a cluster, which was distinct from all other known GBV-C/HGV sequences. None of the South African isolates grouped with group 3 variants described from Southeast Asia. Three variants of GBV-C/HGV exist in KwaZulu Natal groups 1, 2 and a new variant, which is distinct from other African isolates.
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Base de dados:
MEDLINE
Assunto principal:
RNA Viral
/
Homologia de Sequência do Ácido Nucleico
/
Flaviviridae
/
Hepatite Viral Humana
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article