Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function.
Proc Natl Acad Sci U S A
; 96(22): 12548-52, 1999 Oct 26.
Article
em En
| MEDLINE
| ID: mdl-10535959
ABSTRACT
Wnt and its intracellular effector beta-catenin regulate developmental and oncogenic processes. Using expression cloning to identify novel components of the Wnt pathway, we isolated casein kinase Iepsilon (CKIepsilon). CKIepsilon mimicked Wnt in inducing a secondary axis in Xenopus, stabilizing beta-catenin, and stimulating gene transcription in cells. Inhibition of endogenous CKIepsilon by kinase-defective CKIepsilon or CKIepsilon antisense-oligonucleotides attenuated Wnt signaling. CKIepsilon was in a complex with axin and other downstream components of the Wnt pathway, including Dishevelled. CKIepsilon appears to be a positive regulator of the pathway and a link between upstream signals and the complexes that regulate beta-catenin.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Transativadores
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Proteínas Proto-Oncogênicas
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Proteínas do Citoesqueleto
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Proteínas de Peixe-Zebra
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article