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Contraceptive efficacy of daily administration of 0.5 mg mifepristone.
Marions, L; Viski, S; Danielsson, K G; Resch, B A; Swahn, M L; Bygdeman, M; Kovâcs, L.
Afiliação
  • Marions L; Department of Woman and Child Health, Division for Obstetrics and Gynecology, Karolinska Hospital, S-171 76 Stockholm, Sweden.
Hum Reprod ; 14(11): 2788-90, 1999 Nov.
Article em En | MEDLINE | ID: mdl-10548623
The antiprogestin mifepristone has shown potential to be used as a contraceptive. If 200 mg mifepristone is administered immediately after ovulation, the endometrium shows sufficient impairment of secretory development to prevent implantation. Low daily doses of mifepristone have been shown to reduce several of the local factors regarded as crucial for implantation in human endometrium. To find out if this regimen is sufficient to prevent pregnancy, 32 women were recruited for a study where 0.5 mg mifepristone was administered daily. A total of 141 cycles were studied. Five pregnancies occurred, which was significantly less than if no contraceptive method had been used. However, the dose chosen did not seem sufficient to act as a contraceptive although it is probably not possible to increase the dose without disturbing ovulation and bleeding pattern.
Assuntos
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Base de dados: MEDLINE Assunto principal: Mifepristona / Anticoncepcionais Orais Sintéticos Idioma: En Ano de publicação: 1999 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Mifepristona / Anticoncepcionais Orais Sintéticos Idioma: En Ano de publicação: 1999 Tipo de documento: Article