Ethanol opens G-protein-activated inwardly rectifying K+ channels.
Nat Neurosci
; 2(12): 1091-7, 1999 Dec.
Article
em En
| MEDLINE
| ID: mdl-10570486
ABSTRACT
Ethanol affects many functions of the brain and peripheral organs. Here we show that ethanol opens G-protein-activated, inwardly rectifying K + (GIRK) channels, which has important implications for inhibitory regulation of neuronal excitability and heart rate. At pharmacologically relevant concentrations, ethanol activated both brain-type GIRK1/2 and cardiac-type GIRK1/4 channels without interaction with G proteins or second messengers. Moreover, weaver mutant mice, which have a missense mutation in the GIRK2 channel, showed a loss of ethanol-induced analgesia. These results suggest that the GIRK channels in the brain and heart are important target sites for ethanol.
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Base de dados:
MEDLINE
Assunto principal:
Canais de Potássio
/
Ativação do Canal Iônico
/
Proteínas Heterotriméricas de Ligação ao GTP
/
Canais de Potássio Corretores do Fluxo de Internalização
/
Etanol
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article