[Non-small-cell bronchial cancers: long-term survival after single drug chemotherapy with vinorelbine]. / Cancers bronchiques non à petites cellules: étude des longues survies après monochimiothérapie par Vinorelbine.
Rev Pneumol Clin
; 55(4): 205-10, 1999 Sep.
Article
em Fr
| MEDLINE
| ID: mdl-10573748
ABSTRACT
We studied a cohort of 120 patients with inoperable non-small-cell lung cancer treated with vinorelbin at the dose of 25-30 mg/m2/week in a single drug chemotherapy regimen. Surgery was contraindicated due to staging or to concomitant morbidity. Twenty patients survived 18 months or more. One survivor responded exceptionally, surviving 120 months. The mean dose intensity of Vinorelbine in long-term survivors was 21 mg/m2/week. Objective response was found at multivariate analysis to be a prognostic factor for survival beyond 18 months. Weight loss (< 5 kg) was an unfavorable prognostic factor in patients with metastases.
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Base de dados:
MEDLINE
Assunto principal:
Vimblastina
/
Carcinoma Pulmonar de Células não Pequenas
/
Neoplasias Pulmonares
/
Antineoplásicos Fitogênicos
Idioma:
Fr
Ano de publicação:
1999
Tipo de documento:
Article