Mcl-1 and Bcl-xL are co-regulated by IL-6 in human myeloma cells.
Br J Haematol
; 107(2): 392-5, 1999 Nov.
Article
em En
| MEDLINE
| ID: mdl-10583232
ABSTRACT
Multiple myeloma (MM) is a slowly proliferative malignancy in which malignant plasma cells accumulate within the bone marrow. The expression of several anti-apoptotic proteins was evaluated by immunoblotting in human myeloma cell lines and in highly purified native myeloma cells. Expression of Bcl-xL, Mcl-1 and Bcl-2 was found in most of the samples; expression of Bcl-xL and Mcl-1 seemed to be related on myeloma cells. In a system of apoptosis by growth factor deprivation on myeloma cells, we showed that the effect of Bcl-2 seemed minimal whereas Mcl-1 and Bcl-xL were tightly regulated by interleukin (IL)-6. These findings underline the important role of Mcl-1 and Bcl-xL instead of Bcl-2 in IL-6-induced survival of myeloma cells.
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Base de dados:
MEDLINE
Assunto principal:
Interleucina-6
/
Proteínas Proto-Oncogênicas c-bcl-2
/
Mieloma Múltiplo
/
Proteínas de Neoplasias
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article