Circadian interrelationships among levels of plasma fibrinogen, blood platelets, and serum interleukin-6.
Clin Appl Thromb Hemost
; 5(1): 37-42, 1999 Jan.
Article
em En
| MEDLINE
| ID: mdl-10725981
ABSTRACT
Circadian (24 h) rhythms of fibrinogen, interleukin-6 (IL-6), and platelet levels were studied in 11 males ages 46 to 72 years. Since there is a known circadian rhythm for fibrinogen and IL-6, we postulated that the peak level (acrophase) of fibrinogen would follow the acrophase of IL-6, based on the fact that IL-6 is the stimulus for fibrinogen production in the liver. Platelet levels were measured to show whether there was any correlation with the IL-6 acrophase because it has been reported that IL-6 affects megakaryocytes and platelets in dogs. We found that the acrophase for IL-6 occurred at 0203 h and the acrophase for fibrinogen occurred at 0916 h. Platelet counts peaked at 1656 h. Thus, there was a positive correlation between IL-6 and fibrinogen acrophases and a negative correlation of each with the acrophase for platelets. The positive linkage of IL-6 with fibrinogen in this study suggests that suppression of IL-6 production would lower those peak fibrinogen levels that occur in the morning in association with arterial ischemic events. This could result in fewer arterial ischemic events, especially in the morning.
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Base de dados:
MEDLINE
Assunto principal:
Contagem de Plaquetas
/
Plaquetas
/
Fibrinogênio
/
Interleucina-6
/
Ritmo Circadiano
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article