Immunogenicity of dengue virus type 1 DNA vaccines expressing truncated and full length envelope protein.
Vaccine
; 18(22): 2426-34, 2000 May 08.
Article
em En
| MEDLINE
| ID: mdl-10738100
ABSTRACT
Recombinant plasmid DNA constructs expressing truncated or full-length dengue-1 envelope (E) with or without the pre-membrane (prM) were tested for immunogenicity in mice, as candidate dengue DNA vaccines. Two plasmids, one expressing the N-terminal 80% E and the other expressing prM and full length E were immunogenic in intradermally inoculated mice. The vaccinated mice produced dengue-1 specific antibodies that were both neutralizing and long lasting. Data suggested that the plasmid expressing prM and full length E produced virus like particles in transfected cells, and is probably a better immunogen compared to that expressing 80% E.
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Base de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
Proteínas do Envelope Viral
/
Vacinas de DNA
/
Vírus da Dengue
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article