MHC class II-bound self peptides from autoimmune MRL/lpr mice reveal potential T cell epitopes for autoantibody production in murine systemic lupus erythematosus.
J Immunol
; 164(9): 4697-705, 2000 May 01.
Article
em En
| MEDLINE
| ID: mdl-10779775
ABSTRACT
The systemic lupus erythematosus-like syndrome in MRL/lpr mice involves high-titered IgG autoantibodies, particularly antinuclear Abs that target histones, DNA, and RNA particles. Although T cell help is required for the generation of antinuclear Abs, the epitopes recognized by such helper T cells are unknown. To address this question, we isolated and sequenced self peptides bound by MHC class II molecules from MRL/lpr mice. We identified a number of peptides that are not seen in similar preparations from nonautoimmune C3H animals. The "abnormal" peptide donors include histone, a protein component of a small nuclear ribonucleoprotein, ribosomal proteins, and RNA processing enzymes. We postulate that the peptides from these donors are T cell epitopes required for the generation of the most frequent antinuclear Abs specificities seen in MRL/lpr mice.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Autoanticorpos
/
Autoantígenos
/
Antígenos de Histocompatibilidade Classe II
/
Epitopos de Linfócito T
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Lúpus Eritematoso Sistêmico
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article