Evaluation of a neonatal rat model for prediction of mumps virus neurovirulence in humans.

Rubin, S A; Pletnikov, M; Taffs, R; Snoy, P J; Kobasa, D; Brown, E G; Wright, K E; Carbone, K M

Rubin, S A; Pletnikov, M; Taffs, R; Snoy, P J; Kobasa, D; Brown, E G; Wright, K E; Carbone, K M.

Afiliação

Rubin SA; Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA. rubins@cber.fda.gov

J Virol ; 74(11): 5382-4, 2000 Jun.

Article em En | MEDLINE | ID: mdl-10799619

RESUMO

Neurovirulence of several mumps virus strains was assessed in a prototype rat neurovirulence test and compared to results obtained in the monkey neurovirulence test. The relative human neurovirulence of these strains was proportional to the severity of hydrocephalus in rats but not to lesion scores in the monkeys.

Assuntos

Modelos Animais de Doenças; Vírus da Caxumba/patogenicidade; Neurônios/virologia; Animais; Animais Recém-Nascidos; Humanos; Ratos; Virulência

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Modelos Animais de Doenças / Vírus da Caxumba / Neurônios Idioma: En Ano de publicação: 2000 Tipo de documento: Article

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