Growth inhibition and synergistic induction of apoptosis by zoledronate and dexamethasone in human myeloma cell lines.
Leukemia
; 14(5): 841-4, 2000 May.
Article
em En
| MEDLINE
| ID: mdl-10803515
ABSTRACT
Bisphosphonates (BPs) are commonly used in the treatment of myeloma-associated osteolytic lesions. Recent reports have suggested that BPs may also exert direct antitumor effects on myeloma cells. Here, we show that the treatment of myeloma cell lines with the combination of the potent BP zoledronate and dexamethasone inhibits cell growth and synergistically induces apoptotic cell death, providing a rationale for potential applications in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Dexametasona
/
Divisão Celular
/
Apoptose
/
Difosfonatos
/
Imidazóis
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article