Solid phase syntheses of polyamine toxins HO-416b and PhTX-433. Use of an efficient polyamide reduction strategy that facilitates access to branched analogues.
Org Lett
; 2(11): 1581-3, 2000 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-10841484
ABSTRACT
[structure--se text] Polyamine toxins HO-416b (1) and PhTX-433 (2) isolated from the venom of insects are important lead compounds in neuropharmacology. Their total synthesis has been achieved on a trityl derivatized resin in good yield and purity using a mild borane reduction protocol to access the polyamine chains from polyamide precursors. The synthesis of PhTX isomer 3 demonstrates the potential of this strategy for the generation of branched analogues.
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Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Indóis
/
Neurotoxinas
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article