Oxaliplatin, 5-fluorouracil, and folinic acid (Folfox) in patients with metastatic renal cell carcinoma: results of a pilot study.
Am J Clin Oncol
; 23(3): 288-9, 2000 Jun.
Article
em En
| MEDLINE
| ID: mdl-10857895
ABSTRACT
We report the results of a chemotherapy regimen combining oxaliplatin, 5-fluorouracil, and folinic acid in patients with metastatic renal cell carcinoma. The objective of this pilot study was to define the potential efficacy of this second-line combination in patients previously treated with interleukin-2 alone or in combination with interferon alpha. Fourteen patients with metastatic renal cell carcinoma in failure after immunotherapy were included in this trial. During treatment, patients received six chemotherapy courses (Folfox regimen) administered every 2 weeks. Each cycle combined oxaliplatin day (D) D1 and folinic acid plus 5-fluorouracil D1 and D2. At completion of treatment, no objective response was observed and two patients presented stable disease. This chemotherapy schedule in patients with metastatic renal cell carcinoma previously treated with immunotherapy does not seem to be effective.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Neoplasias Renais
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article