Conversion of quassinoids for enhancement of inhibitory effect against Epstein-Barr virus early antigen activation. Introduction of lipophilic side chain and esterification of diosphenol.

Tamura, S; Fukamiya, N; Mou, X Y; Mukainaka, T; Tokuda, H; Nishino, H; Tagahara, K; Koike, K; Lee, K H; Okano, M

Tamura, S; Fukamiya, N; Mou, X Y; Mukainaka, T; Tokuda, H; Nishino, H; Tagahara, K; Koike, K; Lee, K H; Okano, M.

Afiliação

Tamura S; Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashi-Hiroshima, Japan.

Chem Pharm Bull (Tokyo) ; 48(6): 876-8, 2000 Jun.

Article em En | MEDLINE | ID: mdl-10866153

ABSTRACT

ABSTRACT

Introduction of a senecioyl group into shinjulactones B and C, and esterification of the diosphenol moiety in brusatol and brucein A enhanced inhibitory effect against Epstein-Barr virus early antigen activation.

Assuntos

Antígenos Virais/efeitos dos fármacos; Flavonoides/química; Flavonoides/farmacologia; Fenóis/química; Esterificação; Análise Espectral

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Base de dados: MEDLINE Assunto principal: Fenóis / Flavonoides / Antígenos Virais Idioma: En Ano de publicação: 2000 Tipo de documento: Article

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PubMed Links

Base de dados: MEDLINE Assunto principal: Fenóis / Flavonoides / Antígenos Virais Idioma: En Ano de publicação: 2000 Tipo de documento: Article