Expression of measles virus antigens in Streptococcus gordonii.
New Microbiol
; 23(2): 119-28, 2000 Apr.
Article
em En
| MEDLINE
| ID: mdl-10872681
ABSTRACT
The measles virus proteins haemagglutinin (HA) and fusion protein (F), which together mediate attachment and penetration of the virus in the host cell and can elicit production of neutralising antibodies in the course of natural infection were expressed in the vaccine vector Streptococcus gordonii, a Gram-positive bacterium normally present in the human oral cavity. HA and F were expressed as fusion proteins attached to the bacterial surface, and were both found to be immunogenic when the recombinant S. gordonii were inoculated subcutaneously in mice.
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Base de dados:
MEDLINE
Assunto principal:
Streptococcus
/
Proteínas Recombinantes
/
Vacina contra Sarampo
/
Antígenos Virais
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article