Decrease of hindpaw withdrawal latency by cocaine- and amphetamine-regulated transcript peptide to the mouse spinal cord.
Eur J Pharmacol
; 399(2-3): 165-9, 2000 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-10884516
ABSTRACT
Immunohistochemical studies with the use of an antiserum against the cocaine- and amphetamine-regulated transcript (CART) peptide-(55-102) showed an abundance of CART-immunoreactive fibers in the mouse dorsal horn laminae I and II. A few CART-positive somata were scattered in the dorsal horn and around the central canal. Intrathecal injection of the CART peptide-(55-102) at doses 3, 10 and 100 ng caused a dose-dependent and significant decrease of paw withdrawal latency; whereas, saline injection was without significant effect. Our results provide the first evidence that CART-immunoreactive fibers are present in the dorsal horn and that the peptide administered intrathecally produces hyperalgesia, as assessed by paw withdrawal latency in mice.
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Base de dados:
MEDLINE
Assunto principal:
Dor
/
Proteínas do Tecido Nervoso
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article