Mice lacking in gp91 phox subunit of NAD(P)H oxidase showed glomus cell [Ca(2+)](i) and respiratory responses to hypoxia.
Brain Res
; 872(1-2): 188-93, 2000 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-10924691
ABSTRACT
The hypothesis that NAD(P)H oxidase may serve as an oxygen sensor was tested using the mice deficient (knock-out) in gp91phox subunit of NAD(P)H oxidase enzyme complex and compared with wild-type (C57BL/6J) strain measuring the ventilatory and glomus cell intracellular calcium ([Ca(2+)](i)) responses of carotid body to hypoxia. The hypoxic ventilatory responses as well as the [Ca(2+)](i) were preserved in the NAD(P)H oxidase knock-out mice. NAD(P)H oxidase, though a major source of oxygen radical production, is not the oxygen sensor in mice carotid body.
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Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Corpo Carotídeo
/
Cálcio
/
NADPH Oxidases
/
Doença Granulomatosa Crônica
/
Hipóxia
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article