A new photocleavable linker in solid-phase chemistry for ether cleavage
Org Lett
; 2(15): 2315-7, 2000 Jul 27.
Article
em En
| MEDLINE
| ID: mdl-10930272
ABSTRACT
We have designed a new linker (1) for the solid-phase synthesis that cleaves ether bonds photolytically. The linker was prepared in nine steps and anchored to the support via an amide bond. Photocleavage is a two-step process in which the immobilized alcohols are released by photolytic generation of a radical that undergoes a spontaneous beta-bond scission. The pivaloyl linker (1) was found to cleave off alcohols in high yields and purities. Only traces of acid (pH approximately 5.5) are necessary for an efficient cleavage.
Buscar no Google
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article