Polymethylcarborane as a novel bioactive moiety: derivatives with potent retinoid antagonistic activity.
Bioorg Med Chem Lett
; 10(15): 1733-6, 2000 Aug 07.
Article
em En
| MEDLINE
| ID: mdl-10937735
ABSTRACT
4[(Deca-B-methyl-1,12-dicarba-closo-dodecaboran-1-yl)c arbamoyl]benzoic acid and its congeners showed potent antagonistic activity at concentrations of 10(-7)-10(-8) M on the differentiation-inducing action of retinoids towards human promyelocytic leukemia HL-60 cells. This is the first example of derivatives of polymethylcarborane, which resembles C60 in size, with biological activity.
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Base de dados:
MEDLINE
Assunto principal:
Retinoides
/
Benzoatos
/
Compostos de Boro
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article