Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383.
Bioorg Med Chem Lett
; 10(16): 1811-4, 2000 Aug 21.
Article
em En
| MEDLINE
| ID: mdl-10969974
ABSTRACT
Synthetic analogues of the microbial metabolite SB-219383 have been synthesised with defined stereochemistry. Densely functionalised hydroxylamine containing amino acids were prepared by the addition of a glycine anion equivalent to sugar-derived cyclic nitrones. One of four stereoisomeric dipeptides incorporating these novel amino acids was found to be a potent and selective inhibitor of bacterial tyrosyl tRNA synthetase, suggesting analogous stereochemistry of the natural product.
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Base de dados:
MEDLINE
Assunto principal:
Tirosina-tRNA Ligase
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Inibidores Enzimáticos
/
Furanos
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article