Targeting the dimerization interface for irreversible inhibition of HIV-1 protease.
Bioorg Med Chem Lett
; 10(17): 1901-3, 2000 Sep 04.
Article
em En
| MEDLINE
| ID: mdl-10987413
ABSTRACT
A novel strategy was used to irreversibly inhibit HIV-1 protease. The inhibitor was designed to form a disulfide bond with Cys95, present at the dimerization interface of HIV-1 protease. The inhibitor was shown to be active against HIV-1 protease with K(inact) = 3.7 microM and V(inact) = 0.012 min(-1).
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Base de dados:
MEDLINE
Assunto principal:
Protease de HIV
/
Inibidores da Protease de HIV
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article