Management of women with polycystic ovary syndrome who experienced premature luteinization during clomiphene citrate treatment.
Fertil Steril
; 74(4): 749-52, 2000 Oct.
Article
em En
| MEDLINE
| ID: mdl-11020518
ABSTRACT
OBJECTIVE:
To determine the preferred treatment modality in patients with PCOS who experienced premature luteinization during CC treatment.DESIGN:
Prospective randomized study.SETTING:
Tertiary medical center. PATIENTS Twenty-two infertile women with PCOS demonstrating premature luteinization during at least two consecutive CC cycles.INTERVENTIONS:
Randomized induction of ovulation either with FSH alone or with GnRH agonist combined with FSH for a single treatment cycle. MAIN OUTCOMEMEASURES:
Premature luteinization was defined as serum progesterone >1.5 ng/mL before hCG administration.RESULTS:
Premature luteinization occurred in eight of the 10 patients (80%) in group A and in two of the 12 patients in group B (16.6%). This result corresponds to the higher mean (+/-SD) progesterone level present in group A patients as compared to those in group B (2.0 +/- 1.2 ng/mL vs. 1.2 +/- 0.6 ng/mL, P=0.03). No pregnancies were achieved in group A, whereas the pregnancy rate per cycle observed in group B was 33.3% (4/12). On the day of hCG administration, the maximum mean (+/-SD) estradiol level was significantly lower (P<0.0001) in group A (210.6 +/- 37.9 pg/mL) than in group B (600.3 +/- 253.8 pg/mL). The treatment duration and the number of FSH ampules used did not differ between the groups.CONCLUSIONS:
Pituitary desensitization with GnRH analog in combination with FSH is superior to FSH-only treatment in PCOS patients who demonstrate premature luteinization during CC treatment.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome do Ovário Policístico
/
Hormônio Luteinizante
/
Clomifeno
/
Pamoato de Triptorrelina
/
Gerenciamento Clínico
/
Fármacos para a Fertilidade Feminina
/
Infertilidade Feminina
/
Luteolíticos
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article