Anti-CD2 monoclonal antibodies prevent the induction of experimental autoimmune myocarditis.
Jpn Heart J
; 41(4): 507-17, 2000 Jul.
Article
em En
| MEDLINE
| ID: mdl-11041101
ABSTRACT
We investigated the effect of a monoclonal antibody against CD2 molecules (OX34) in preventing the induction of experimental autoimmune myocarditis (EAM) induced by immunizing Lewis rats with cardiac myosin. Administration of OX34 before immunization, on Days -6, -4, -2 and 0, completely prevented EAM. On the other hand, treatment with OX34 just before the appearance of myocardial lesions, on Days 9, 11, 13 and 15, had only a partial effect in preventing the disease. Flow cytometric analysis of lymph node cells showed that CD3+ T cells were immediately depleted with the administration of OX34 but had largely recovered on Day 21. Lymph node cells in OX34-treated rats had no proliferative responses to cardiac myosin-rod, but the proliferation was restored when recombinant IL-2 was added. Ultimate production of the anti-myosin antibody was not inhibited by the treatment with OX34. These results suggest that the prevention of EAM by administering the anti-CD2 monoclonal antibody OX34 resulted from T cell depletion during the induction phase, and might in addition result from T cell anergy of Th1, but not Th2 cells.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Linfócitos T
/
Anticorpos Monoclonais
/
Miocardite
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article