A practical synthesis of the ABC ring model of ecteinascidins.
Chem Pharm Bull (Tokyo)
; 48(10): 1549-57, 2000 Oct.
Article
em En
| MEDLINE
| ID: mdl-11045468
ABSTRACT
A practical synthesis of 1,2,3,4,5,6-hexahydro-1,5-imino-10-hydroxy-9-methoxy-3,8,11-trimethyl-3- benzazocin-4-one (3) as an ABC ring model compound of ecteinascidin 743 and safracins from 3-hydroxy-4-methoxy-5-methylbenzaldehyde (7) is described. The overall yield in 15 steps is 27%.
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Base de dados:
MEDLINE
Assunto principal:
Modelos Moleculares
/
Dioxóis
/
Isoquinolinas
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article