The influence of tomograph sensitivity on kinetic parameter estimation in positron emission tomography imaging studies of the rat brain.
Nucl Med Biol
; 27(6): 617-25, 2000 Aug.
Article
em En
| MEDLINE
| ID: mdl-11056379
ABSTRACT
We investigated the influence of tomograph sensitivity on reliability of parameter estimation in positron emission tomography studies of the rat brain. The kinetics of two tracers in rat striatum and cerebellum were simulated. A typical injected dose of 10 MBq and a reduced dose of 1 MBq were assumed. Kinetic parameters were estimated using a region of interest (ROI) analysis and two pixel-by-pixel analyses. Striatal binding potential was estimated as a function of effective tomograph sensitivity (S(eff)) using a simplified reference tissue model. A S(eff) value of > or =1% was required to ensure reliable parameter estimation for ROI analysis and a S(eff) of 3-6% was required for pixel-by-pixel analysis. We conclude that effective tomograph sensitivity of 3% may be an appropriate design goal for rat brain imaging.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Membrana Transportadoras
/
Simulação por Computador
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Encéfalo
/
Glicoproteínas de Membrana
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Tomografia Computadorizada de Emissão
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Cocaína
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Modelos Neurológicos
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Proteínas do Tecido Nervoso
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article