Disturbance of cardiovascular circadian rhythms by pertussis vaccine in freely-moving rats.
Lab Anim
; 34(4): 399-402, 2000 Oct.
Article
em En
| MEDLINE
| ID: mdl-11072860
ABSTRACT
Vaccination of young children with diphtheria, tetanus, poliomyelitis and pertussis (DTPoP) vaccine is effective in preventing outbreaks of whooping cough but adverse events sometimes occur. This pilot study shows that in freely-moving rats, multiple treatment with DTPoP (at day 0 and day 5, 6 ml/kg i.v.) increased heart rate (HR) for 5 days after the first treatment and decreased diastolic blood pressure (DBP) for at least 26 days after the first treatment and inhibited the circadian rhythm of HR and DBP for at least 10 days. DTPo vaccine, containing no pertussis vaccine, was free of such effects. Thus, in rats, the pertussis component of DTPoP acts on the cardiovascular system and disturbs its circadian rhythm. The contribution of these findings to clinical adverse effects is as yet unknown and needs further research.
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Base de dados:
MEDLINE
Assunto principal:
Toxoide Diftérico
/
Toxoide Tetânico
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Vacina contra Coqueluche
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Vacina Antipólio de Vírus Inativado
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Sistema Cardiovascular
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Vacina contra Difteria, Tétano e Coqueluche
/
Ritmo Circadiano
/
Vacinas Combinadas
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article