A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma.
Jpn J Cancer Res
; 91(11): 1096-9, 2000 Nov.
Article
em En
| MEDLINE
| ID: mdl-11092972
ABSTRACT
A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan, and named the rising "Nihon" rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are predominantly of clear cell type. Southern blot, northern blot and SSCP analyses revealed no change in the Tsc1, Tsc2, VHL, and c-Met genes. Thus, the Nihon rat should be a valuable experimental model for understanding renal carcinogenesis, especially clear cell type, which is common among human RCs.
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Base de dados:
MEDLINE
Assunto principal:
Carcinoma de Células Renais
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Proteínas Supressoras de Tumor
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Ubiquitina-Proteína Ligases
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Neoplasias Renais
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Ligases
Idioma:
En
Ano de publicação:
2000
Tipo de documento:
Article